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Topic

Real-world evidence

Observational designs, the biases that live in routinely collected data, and how far the conclusions can honestly go.

Guides in this topic

  1. 01Keywords: How Database Indexing Drives Your Paper’s CitationsSearch engines index title words automatically. Keywords exist to add what your title missed—mapping your paper into major database index hierarchies (PubMed MeSH, Embase Emtree) so researchers actually find and cite it.
  2. 02Propensity scores: matching, weighting and what they cannot fixA propensity score balances the variables you measured. It does nothing about the ones you did not, which in observational research are usually the ones that mattered.
  3. 03Immortal time bias, and how to avoid building it into your studyA period during which the outcome could not have happened, assigned to one group by the way the study defines exposure. It reliably makes treatments look protective.
  4. 04What is real-world evidence, and what can it actually answer?Real-world data is data collected for a purpose other than your study. That single fact explains most of both its value and its limits.

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